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O-岩藻糖基转移酶在Notch转运和信号传导中的作用：争议即将结束？

Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

作者信息

Vodovar Nicolas, Schweisguth François

机构信息

Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.

出版信息

J Biol. 2008;7(2):7. doi: 10.1186/jbiol68.

DOI:10.1186/jbiol68
PMID:18312702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2263122/
Abstract

The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.

摘要

O-岩藻糖基转移酶Ofut1在Notch受体运输中的精确作用一直存在争议。最近的一项研究揭示了Ofut1的非催化活性，并提供了进一步的证据表明Ofut1在内质网中充当伴侣蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5235/2263122/d41c0bd786f1/jbiol68-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5235/2263122/d41c0bd786f1/jbiol68-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5235/2263122/d41c0bd786f1/jbiol68-1.jpg

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本文引用的文献

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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.Rumi是一种CAP10结构域糖基转移酶，可修饰Notch，是Notch信号传导所必需的。
Cell. 2008 Jan 25;132(2):247-58. doi: 10.1016/j.cell.2007.12.016.
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The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.Notch1配体结合域中的O-岩藻糖聚糖调节胚胎发育和T细胞发育。
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Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling.
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Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway.蛋白 O-岩藻糖基转移酶 1 的表达通过 Notch 信号通路影响成肌细胞 C2C12 的定向分化。
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Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation.果蝇胚胎中神经特异性 α3-岩藻糖基化 N-连接聚糖需要岩藻糖基转移酶 A，并影响与 O-聚糖有关的发育信号。
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Role of glycans and glycosyltransferases in the regulation of Notch signaling.糖链和糖基转移酶在 Notch 信号通路调控中的作用。
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The canonical Notch signaling pathway: unfolding the activation mechanism.经典Notch信号通路：揭示激活机制
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Regulation of Notch signaling by glycosylation.糖基化对Notch信号通路的调控。
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Notch signaling in normal and disease States: possible therapies related to glycosylation.正常及疾病状态下的Notch信号通路：与糖基化相关的潜在疗法
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The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.O-岩藻糖基转移酶O-fut1是一种细胞外成分，对果蝇中Notch的组成型内吞运输至关重要。
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Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells.Notch在果蝇上皮细胞顶端定位过程中的极化胞吐作用和转胞吞作用。
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Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.蛋白质O-岩藻糖基转移酶1的伴侣活性促进Notch受体折叠。
Science. 2005 Mar 11;307(5715):1599-603. doi: 10.1126/science.1108995. Epub 2005 Feb 3.
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O-fucosylation of notch occurs in the endoplasmic reticulum.Notch蛋白的O-岩藻糖基化发生在内质网中。
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