O-岩藻糖基转移酶在Notch转运和信号传导中的作用：争议即将结束？
Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?
作者信息
Vodovar Nicolas, Schweisguth François
机构信息
Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.
出版信息
J Biol. 2008;7(2):7. doi: 10.1186/jbiol68.
Abstract
The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.
摘要
O-岩藻糖基转移酶Ofut1在Notch受体运输中的精确作用一直存在争议。最近的一项研究揭示了Ofut1的非催化活性，并提供了进一步的证据表明Ofut1在内质网中充当伴侣蛋白。
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