一种剖析性别二态性行为的遗传学方法。
A genetic approach to dissect sexually dimorphic behaviors.
作者信息
Juntti Scott A, Coats Jennifer K, Shah Nirao M
机构信息
Neuroscience Graduate Program, Department of Anatomy, University of California, San Francisco, 1550 4th Street, MC2722, CA 94158, USA.
出版信息
Horm Behav. 2008 May;53(5):627-37. doi: 10.1016/j.yhbeh.2007.12.012. Epub 2008 Jan 5.
Abstract
It has been known since antiquity that gender-specific behaviors are regulated by the gonads. We now know that testosterone is required for the appropriate display of male patterns of behavior. Estrogen and progesterone, on the other hand, are essential for female typical responses. Research from several groups also indicates that estrogen signaling is required for male typical behaviors. This finding raises the issue of the relative contribution of these two hormonal systems in the control of male typical behavioral displays. In this review we discuss the findings that led to these conclusions and suggest various genetic strategies that may be required to understand the relative roles of testosterone and estrogen signaling in the control of gender-specific behavior.
摘要
自古以来就知道，性别特异性行为受性腺调节。我们现在知道，睾酮是适当展现男性行为模式所必需的。另一方面，雌激素和孕酮对于女性典型反应至关重要。多个研究小组的研究还表明，男性典型行为需要雌激素信号传导。这一发现引发了关于这两种激素系统在控制男性典型行为表现中相对作用的问题。在这篇综述中，我们讨论了得出这些结论的研究结果，并提出了各种可能需要的遗传策略，以了解睾酮和雌激素信号传导在控制性别特异性行为中的相对作用。
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3
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5
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6
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J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):185-200. doi: 10.1016/0960-0760(95)00236-7.
7
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8
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9
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本文引用的文献
1
The effect of male hormone on aggressive behavior in mice.
Physiol Zool. 1947 Oct;20(4):373-405. doi: 10.1086/physzool.20.4.30151969.
2
Rapid actions of androgens.
Front Neuroendocrinol. 2008 May;29(2):182-98. doi: 10.1016/j.yfrne.2007.08.004. Epub 2007 Oct 5.
3
Inducible gene inactivation in neurons of the adult mouse forebrain.
BMC Neurosci. 2007 Aug 2;8:63. doi: 10.1186/1471-2202-8-63.
4
The ram as a model for behavioral neuroendocrinology.
Horm Behav. 2007 Jun;52(1):70-7. doi: 10.1016/j.yhbeh.2007.03.016. Epub 2007 Mar 31.
5
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system.
J Endocrinol. 2007 May;193(2):311-21. doi: 10.1677/JOE-07-0017.
6
Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice.
Eur J Neurosci. 2007 Apr;25(7):2182-90. doi: 10.1111/j.1460-9568.2007.05484.x.
7
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories.
Mol Psychiatry. 2007 Jul;12(7):656-70. doi: 10.1038/sj.mp.4001957. Epub 2007 Jan 30.
8
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.
Cell. 2006 Dec 15;127(6):1253-64. doi: 10.1016/j.cell.2006.10.041.
9
Genome-wide atlas of gene expression in the adult mouse brain.
Nature. 2007 Jan 11;445(7124):168-76. doi: 10.1038/nature05453. Epub 2006 Dec 6.
10
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice.
Genesis. 2006 Dec;44(12):611-21. doi: 10.1002/dvg.20256.
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