Castanheira Mariana, Jones Ronald N, Sader Hélio S
JMI Laboratories, North Liberty, IA 52317, USA.
Diagn Microbiol Infect Dis. 2008 Jun;61(2):235-9. doi: 10.1016/j.diagmicrobio.2008.01.016. Epub 2008 Mar 7.
Gram-positive bacterial strains (6710) consecutively collected during 2006 in hospitals located in the United States and Canada were tested by reference broth microdilution methods against daptomycin and comparison agents. Only 1 Staphylococcus aureus strain (0.01%) had nonsusceptible daptomycin MIC value as specified by published break points. S. aureus daptomycin MIC distributions from 2006 as compared with those of previous years did not show "MIC creep". Resistance to other compounds, such as vancomycin, oxacillin, and penicillin, did not adversely influence daptomycin activity. Daptomycin remains highly active against clinical Gram-positive isolates collected in North America.
2006年期间在美国和加拿大医院连续收集的6710株革兰氏阳性菌菌株，采用参考肉汤微量稀释法对达托霉素及对照药物进行了检测。按照已公布的断点标准，只有1株金黄色葡萄球菌菌株（0.01%）的达托霉素最低抑菌浓度（MIC）值不敏感。与前几年相比，2006年金黄色葡萄球菌的达托霉素MIC分布未显示出“MIC漂移”。对其他化合物（如万古霉素、苯唑西林和青霉素）的耐药性并未对达托霉素的活性产生不利影响。达托霉素对在北美收集的临床革兰氏阳性分离株仍保持高度活性。
