Roessner A
Institut für Pathologie, Universitäitsklinikum Magdeburg.
Verh Dtsch Ges Pathol. 2007;91:83-6.
The primary round cell tumors of the skeletal system focus on the differential diagnosis of Ewing sarcoma. It is known that this tumor can be defined on the basis of translocation 11; 22. Therefore, in most cases, the differential diagnosis to other "round cell" tumors of the skeletal system no longer causes great problems. Besides the differential diagnosis of chondrogenic tumors, the diagnosis of osteoid-forming tumors is very problematic histologically. Focus of attention is the diagnosis of highly malignant osteosarcoma. This must be differentiated from the low malignant, intramedullary osteosarcomas, as well as from benign, osteoid-forming tumors and -like tumors. Especially the tumors located at the border between highly malignant osteosarcoma and benign osteoblastoma are difficult as far as the differential diagnosis is concerned. These cases are so rare that they are dealt with only at a casuistic level. Therefore, with regard to their classification, there have been almost no changes recently.
骨骼系统的原发性圆形细胞瘤主要关注尤因肉瘤的鉴别诊断。已知这种肿瘤可根据11号和22号染色体易位来定义。因此，在大多数情况下，与骨骼系统其他“圆形细胞”肿瘤的鉴别诊断不再造成大的问题。除了软骨源性肿瘤的鉴别诊断外，骨样形成肿瘤的组织学诊断非常困难。备受关注的是高恶性骨肉瘤的诊断。这必须与低恶性的髓内骨肉瘤以及良性骨样形成肿瘤和类肿瘤相鉴别。就鉴别诊断而言，特别是位于高恶性骨肉瘤和良性骨母细胞瘤之间边界处的肿瘤很难诊断。这些病例非常罕见，仅在个案层面进行处理。因此，就其分类而言，最近几乎没有变化。
