Synthesis of carbamoyl azides from primary amines and carbon dioxide under mild conditions.
作者信息
García-Egido Eduardo, Fernandez-Suarez Miryam, Muñoz Luis
机构信息
Departamento de Química OrgAnica, Universidade de Vigo, E-36310 Vigo, Spain.
出版信息
J Org Chem. 2008 Apr 4;73(7):2909-11. doi: 10.1021/jo702506v. Epub 2008 Mar 4.
PMID:18315006
Abstract
Treatment of amines under a carbon dioxide atmosphere with tetramethylphenylguanidine (PhTMG) and diphenylphosphoryl azide (DPPA) in acetonitrile below 0 degrees C provides carbamoyl azides in high to excellent yields. In addition, epimerization is not observed when optically pure alpha-amino esters are used as substrates.
摘要
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