Cesbron-Delauw Marie-France, Gendrin Claire, Travier Laetitia, Ruffiot Pauline, Mercier Corinne
Laboratoire Adaptation et Pathogénie des Microorganismes, CNRS UMR 5163, Université Joseph Fourier - Grenoble 1, BP 170, 38042 Grenoble Cedex 9, France.
Traffic. 2008 May;9(5):657-64. doi: 10.1111/j.1600-0854.2008.00728.x. Epub 2008 Feb 24.
Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components. Trafficking of parasite-encoded proteins destined to membrane compartments beyond the confine of the parasite plasma membrane is a process that offers a rich territory to explore novel mechanisms of protein-membrane interactions. Here, we focus on the PVs formed by the asexual stages of two pathogens of medical importance, Plasmodium and Toxoplasma. We compare the PVs of both parasites, with a particular emphasis on their evolutionary divergent compartmentalization within the host cell. We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post-secretory targeting of parasite proteins to the PV subcompartments.
大多数顶复门原虫在其宿主细胞的细胞质中生存和繁殖，位于源自寄生虫和宿主细胞成分的寄生泡（PV）内。将寄生虫编码的蛋白质运输到寄生虫质膜范围之外的膜区室是一个过程，为探索蛋白质 - 膜相互作用的新机制提供了丰富的领域。在这里，我们重点关注由两种具有医学重要性的病原体——疟原虫和弓形虫的无性阶段形成的寄生泡。我们比较了这两种寄生虫的寄生泡，特别强调它们在宿主细胞内进化上不同的区室化。我们还讨论了可能参与寄生虫蛋白质分泌后靶向寄生泡亚区室的特殊输出机制和/或分选决定因素的存在情况。
