III, Medical Clinic, Dept, of Pulmonary Medicine, Johannes-Gutenberg-University, Langenbeckstr, 1, 55101 Mainz, Germany.
J Occup Med Toxicol. 2008 Feb 27;3 Suppl 1(Suppl 1):S2. doi: 10.1186/1745-6673-3-S1-S2.
Murine models have highlighted the importance of T-cells and TH2 cytokines in development of allergen-induced airway disease. In contrast, the role of mast cells for the development of allergic airway disease has been controversial. Recent studies in murine models demonstrate a significant contribution of mast cells during the development of airway hyperresponsiveness and airway inflammation. Furthermore these models have allowed identifying certain mast cell-produced mediators (e.g. histamine and leukotriene B4) to be involved in the recruitment of effector T-cells into the lung. Additionally, mast cell-produced TNF can directly activate TH2 cells and contribute to the development of allergic airway disease. These new findings demonstrate a complex role of mast cells and their mediators, not only as effector cells, but also during sensitization and development of allergic airway disease. Therefore mast cells and certain mast cell-produced mediators might be an interesting target for the prevention and treatment of allergic asthma.
鼠类模型突出了 T 细胞和 TH2 细胞因子在变应原诱导的气道疾病发展中的重要性。相比之下，肥大细胞在过敏性气道疾病发展中的作用一直存在争议。最近的鼠类模型研究表明，肥大细胞在气道高反应性和气道炎症的发展过程中具有重要作用。此外，这些模型还确定了某些肥大细胞产生的介质（例如组胺和白三烯 B4）参与效应 T 细胞向肺部的募集。此外，肥大细胞产生的 TNF 可以直接激活 TH2 细胞，并有助于过敏性气道疾病的发展。这些新发现表明肥大细胞及其介质不仅作为效应细胞，而且在致敏和过敏性气道疾病发展过程中具有复杂的作用。因此，肥大细胞和某些肥大细胞产生的介质可能是预防和治疗过敏性哮喘的一个有趣的靶点。
