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[异基因造血干细胞移植后树突状细胞的重建动力学]

[Reconstitution kinetics of dendritic cells following allogeneic hematopoietic stem cell transplantation].

作者信息

Fu Hai-Xia, Zhang Xiao-Hui

机构信息

Institute of Hematology, People Hospital, Peking University, Beijing 100044, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Feb;16(1):222-6.

Abstract

As the most important antigen present cells in the processes of post-transplant complications in vivo, dendritic cells (DCs) play an important role in graft versus host disease (GVHD), infection, and relapse. DCs have became one of the most critical problems in the transplantation immune research recently. The reconstitution kinetics of circulating DCs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its relationship with the post-transplant complications, even the promoter or inhibitor affecting this process are summarized in this review.

摘要

作为体内移植后并发症过程中最重要的抗原呈递细胞,树突状细胞(DCs)在移植物抗宿主病(GVHD)、感染和复发中起重要作用。DCs已成为近期移植免疫研究中最关键的问题之一。本文综述了异基因造血干细胞移植(allo-HSCT)后循环DCs的重建动力学及其与移植后并发症的关系,甚至包括影响这一过程的促进剂或抑制剂。

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