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Myoclonic epileptic seizures during clozapine treatment: a report of three cases.

作者信息

Gouzoulis E, Grunze H, von Bardeleben U

机构信息

Department of Psychiatry, University of Freiburg, Federal Republic of Germany.

出版信息

Eur Arch Psychiatry Clin Neurosci. 1991;240(6):370-2. doi: 10.1007/BF02279769.

DOI:10.1007/BF02279769
PMID:1831670
Abstract

Three adult schizophrenic patients without a previous history of epilepsy are reported who, during clozapine treatment, developed paroxysmal EEG patterns and generalized myoclonic jerks without alteration of consciousness. These seizures were phenomenologically identical to those occurring in juvenile myoclonic epilepsy and were classified as generalized epileptic seizures. We tentatively conclude that generalized myoclonic epileptic seizures may be induced by clozapine.

摘要

相似文献

1
Myoclonic epileptic seizures during clozapine treatment: a report of three cases.
Eur Arch Psychiatry Clin Neurosci. 1991;240(6):370-2. doi: 10.1007/BF02279769.
2
Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment.
Psychiatry Res. 1992 Nov;44(2):107-12. doi: 10.1016/0165-1781(92)90045-5.
3
[EEG changes and seizures with clozapine medication in schizophrenic adolescents].
Z Kinder Jugendpsychiatr. 1991;19(3):164-9.
4
Clozapine and seizures.氯氮平与癫痫发作。
Biol Psychiatry. 1995 Apr 1;37(7):427-33. doi: 10.1016/0006-3223(94)00237-W.
5
Clozapine-induced myoclonus and generalized seizures.氯氮平所致肌阵挛和全身性癫痫发作。
Biol Psychiatry. 1996 Mar 1;39(5):367-70. doi: 10.1016/0006-3223(95)00499-8.
6
Myoclonic seizures and "leg folding" phenomena with clozapine therapy: report of two cases.氯氮平治疗相关的肌阵挛发作和“腿部折叠”现象：两例报告。
Biol Psychiatry. 1994 Dec 1;36(11):759-62. doi: 10.1016/0006-3223(94)90087-6.
7
Seizures during clozapine therapy.氯氮平治疗期间的癫痫发作。
J Clin Psychiatry. 1994 Sep;55 Suppl B:153-6.
8
Clinical observations of juvenile myoclonic epilepsy in 131 patients: a study in South India.131例青少年肌阵挛癫痫的临床观察：一项在印度南部开展的研究。
Seizure. 1998 Feb;7(1):43-7. doi: 10.1016/s1059-1311(98)90007-3.
9
[Generalized epileptic seizures in treatment with clozapine. Incidence, types, prognosis and recommendations with reference to therapeutic strategies].[氯氮平治疗中的全身性癫痫发作。发病率、类型、预后及针对治疗策略的建议]
Nervenarzt. 1994 Nov;65(11):792-4.
10
Clozapine-induced EEG abnormalities and clinical response to clozapine.氯氮平诱发的脑电图异常及对氯氮平的临床反应。
J Neuropsychiatry Clin Neurosci. 1995 Fall;7(4):466-70. doi: 10.1176/jnp.7.4.466.

引用本文的文献

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Electric Shock Sensation and Recurrent Falls as a Side Effect of Clozapine Therapy: A Case Report.电击感和反复跌倒作为氯氮平治疗的副作用：一例报告
Cureus. 2024 May 26;16(5):e61143. doi: 10.7759/cureus.61143. eCollection 2024 May.
2
Clozapine-induced myoclonus: a case report and review of the literature.氯氮平所致肌阵挛：一例报告及文献复习
Ther Adv Psychopharmacol. 2015 Dec;5(6):351-6. doi: 10.1177/2045125315612015.
3
Clozapine-related EEG changes and seizures: dose and plasma-level relationships.氯氮平相关的脑电图变化和癫痫发作：剂量与血浆浓度的关系。

本文引用的文献

1
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2
Tolerability and therapeutic effect of clozapine. A retrospective investigation of 216 patients treated with clozapine for up to 12 years.氯氮平的耐受性与治疗效果。对216例接受氯氮平治疗长达12年的患者进行的回顾性调查。
Acta Psychiatr Scand. 1985 Feb;71(2):176-85. doi: 10.1111/j.1600-0447.1985.tb01268.x.
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The effect of long-term treatment with clozapine in schizophrenia: a retrospective study in 96 patients treated with clozapine for up to 13 years.
氯氮平长期治疗精神分裂症的效果：一项对96例接受氯氮平治疗长达13年患者的回顾性研究。
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4
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.氯氮平用于难治性精神分裂症。与氯丙嗪的双盲对照研究。
Arch Gen Psychiatry. 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001.
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Side effects of clozapine.氯氮平的副作用。
Psychopharmacology (Berl). 1989;99 Suppl:S97-100. doi: 10.1007/BF00442570.
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Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia--a retrospective study of 387 patients.
Psychopharmacology (Berl). 1989;99 Suppl:S73-6. doi: 10.1007/BF00442564.
7
A prospective study of clozapine in treatment-resistant schizophrenic patients. I. Preliminary report.
Psychopharmacology (Berl). 1989;99 Suppl:S68-72. doi: 10.1007/BF00442563.
8
Adverse effects of clozapine.氯氮平的不良反应。
Psychopharmacology (Berl). 1989;99 Suppl:S101-4. doi: 10.1007/BF00442571.
9
Drug-induced paroxysmal EEG-activities.药物诱发的阵发性脑电图活动。
Pharmakopsychiatr Neuropsychopharmakol. 1979 Mar;12(2):165-72. doi: 10.1055/s-0028-1094607.
10
[The incidence of abnormal EEG patterns with clozapine therapy (author's transl)].氯氮平治疗时异常脑电图模式的发生率（作者译）
Arzneimittelforschung. 1978;28(9):1499-500.