HooKim Kim, deRoux Stephen, Igbokwe Anne, Stanek Albert, Koo Jaik, Hsu Jean, Pincus Matthew R, Bluth Martin H
Department of Pathology, SUNY Downstate Medical Center, Box 40, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Ann Clin Lab Sci. 2008 Winter;38(1):83-7.
Giant cell myocarditis, a rare, fatal, and poorly understood cause of myocarditis, requires pathological examination for diagnosis. It is considered to be an autoimmune disease and is frequently associated with other conditions, in particular thymoma and myasthenia gravis. The typical patient with giant cell myocarditis is young and has severe, progressive congestive cardiac failure that is unresponsive to standard medical therapy and ultimately requires cardiac transplantation. Hence giant cell myocarditis is the most dangerous form of myocarditis. Here we report an unusual presentation of giant cell myocarditis, which mimicked acute myocardial infarction in an elderly woman with myasthenia gravis and a previous diagnosis of thymoma. This patient had evidence of anti-myocyte antibodies, consistent with an autoimmune mechanism.
巨细胞性心肌炎是一种罕见、致命且了解甚少的心肌炎病因，诊断需要进行病理检查。它被认为是一种自身免疫性疾病，常与其他病症相关，尤其是胸腺瘤和重症肌无力。巨细胞性心肌炎的典型患者较为年轻，患有严重的进行性充血性心力衰竭，对标准药物治疗无反应，最终需要进行心脏移植。因此，巨细胞性心肌炎是心肌炎最危险的形式。在此，我们报告一例不寻常的巨细胞性心肌炎表现，该病例在一名患有重症肌无力且既往诊断为胸腺瘤的老年女性中酷似急性心肌梗死。该患者有抗心肌抗体证据，符合自身免疫机制。
