患有镰状细胞病和人类免疫缺陷病毒感染的儿科患者中头孢曲松诱导的红细胞抗体的患病率。

Prevalence of ceftriaxone-induced red blood cell antibodies in pediatric patients with sickle cell disease and human immunodeficiency virus infection.

作者信息

Quillen Karen, Lane Catherine, Hu Edward, Pelton Stephen, Bateman Scot

机构信息

Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, MA 02118, USA.

出版信息

Pediatr Infect Dis J. 2008 Apr;27(4):357-8. doi: 10.1097/INF.0b013e3181629a55.

DOI:10.1097/INF.0b013e3181629a55

PMID:18316983

Abstract

Ceftriaxone can be associated with catastrophic immune hemolysis in pediatric patients, particularly those with underlying diseases such as sickle cell disease and human immunodeficiency virus infection. We designed a study to screen for ceftriaxone-induced RBC antibodies in these 2 pediatric populations. The prevalence of anticeftriaxone antibody was 12.5% (8 of 64). Two of these 8 patients with the antibody experienced hemolysis; 1 case was fatal.

摘要

头孢曲松可与儿科患者的灾难性免疫性溶血相关，尤其是那些患有镰状细胞病和人类免疫缺陷病毒感染等基础疾病的患者。我们设计了一项研究，以筛查这两类儿科人群中头孢曲松诱导的红细胞抗体。抗头孢曲松抗体的患病率为12.5%（64例中有8例）。这8例有抗体的患者中有2例发生了溶血；1例死亡。