Xiao D
Institute of Basic Medical Sciences, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1991 Apr;13(2):125-8.
The hemodynamic effect of diprenorphine (M5050) in canine endotoxic shock was studied. Mean arterial pressure, left ventricular pressure, left ventricular contractility (dp/dt max), stroke volume, and cardiac output in the endotoxin-shocked dogs were significantly improved by intravenous injection of naloxone (2 mg/kg) and intraventricular microinjection of diprenorphine (40 micrograms), but not by intravenous injection of diprenorphine. It was suggested that the site of action of diprenorphine might be in the central nervous system, and the endogenous opioid substances in the central nervous system may play a more important role in the pathogenesis of septic shock than does that in the peripheral system.
研究了二丙诺啡（M5050）对犬内毒素休克的血流动力学影响。静脉注射纳洛酮（2mg/kg）和脑室内微量注射二丙诺啡（40μg）可显著改善内毒素休克犬的平均动脉压、左心室压力、左心室收缩力（dp/dt max）、每搏量和心输出量，但静脉注射二丙诺啡则无此作用。提示二丙诺啡的作用部位可能在中枢神经系统，且中枢神经系统中的内源性阿片类物质在脓毒症休克发病机制中可能比外周系统中的内源性阿片类物质起更重要的作用。
