Horn Lars-Christian, Liebert Uwe G, Edelmann Jeanett, Höckel Michael, Einenkel Jens
Institute of Pathology, Division of Gynecologic Pathology, Leipzig University, Leipzig, Germany.
Int J Gynecol Pathol. 2008 Apr;27(2):288-91. doi: 10.1097/PGP.0b013e3181569904.
Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology. We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs. Molecular analysis did not reveal any human papillomavirus infection. Because of the positive p53 immunostaining and the association to lichen sclerosus and simple type of high-grade vulvar intraepithelial neoplasia, alteration of p53 tumor suppressor gene might be involved in the pathogenesis of vulvar pseudoangiosarcomatous squamous cell carcinoma. However, further molecular studies are required.
假血管肉瘤样鳞状细胞癌是一种罕见但侵袭性强的外阴棘层松解性鳞状细胞癌变体，在组织学上类似血管肉瘤。我们报告一例57岁女性，诊断时已有双侧腹股沟转移，4个月后因肺远处转移死亡。分子分析未发现人乳头瘤病毒感染。由于p53免疫染色阳性以及与硬化性苔藓和单纯型高级别外阴上皮内瘤变相关，p53肿瘤抑制基因改变可能参与了外阴假血管肉瘤样鳞状细胞癌的发病机制。然而，还需要进一步的分子研究。
