Isaias Ioannis U, Canesi Margherita, Benti Riccardo, Gerundini Paolo, Cilia Roberto, Pezzoli Gianni, Antonini Angelo
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.
Nucl Med Commun. 2008 Apr;29(4):349-53. doi: 10.1097/MNM.0b013e3282f4d307.
We used (123)I-Ioflupane SPECT to study 32 unrelated patients with essential tremor (16 with positive familial history), 47 sporadic tremor dominant patients with Parkinson's disease and 31 healthy control subjects. Discriminant analysis was used to categorize healthy subjects and patients with Parkinson's disease or essential tremor.
Patients with essential tremor had higher uptake values (50% putamen and 21% caudate, P<0.001) compared to those with Parkinson's disease but lower than healthy subjects (15% putamen and 21% caudate, P<0.05). Discriminant analysis classified seven essential tremor patients in the healthy subjects cohort (22%) and two as Parkinson's disease (6%).
Our results show that some essential tremor patients may present mild abnormalities of striatal dopamine transporters and a typical Parkinson's disease-like pattern of uptake loss. These findings suggest a link between the two disorders.
我们使用（123）I - 碘氟烷单光子发射计算机断层扫描（SPECT）研究了32例无亲缘关系的特发性震颤患者（16例有阳性家族史）、47例散发的震颤为主型帕金森病患者以及31名健康对照者。采用判别分析对健康受试者以及帕金森病或特发性震颤患者进行分类。
与帕金森病患者相比，特发性震颤患者的摄取值更高（壳核为50%，尾状核为21%，P<0.001），但低于健康受试者（壳核为15%，尾状核为21%，P<0.05）。判别分析将7例特发性震颤患者归类到健康受试者队列中（22%），2例归类为帕金森病（6%）。
我们的结果表明，一些特发性震颤患者可能存在纹状体多巴胺转运体的轻度异常以及典型的帕金森病样摄取减少模式。这些发现提示了这两种疾病之间的联系。
