[莫西沙星与巨噬细胞清道夫受体配体缀合物的抗结核活性研究]
[Study of antituberculous activity of moxifloxacin conjugate with macrophage scavenger-receptor ligand].
作者信息
Azaev M Sh, Agafonov A P, Bodnev S A, Blinov V M
出版信息
Antibiot Khimioter. 2006;51(11-12):7-10.
Mycobacterium tuberculosis is an intracellular pathogen that persists in macrophages of the human host. An approach to improving the treatment of tuberculosis is target delivery of antibiotics to macrophages using ligands to macrophage receptors. The antituberculous activity of the conjugate of the antituberculous antibiotic moxifloxacin with carboxymethylglucan was studied in vitro using the J774 macrophage cell line and peritoneal macrophages. The antituberculous activity of the conjugate was higher than of the free moxifloxacin. The target antibiotic delivery to macrophage cells in tuberculosis infection was shown perspective.
结核分枝杆菌是一种胞内病原体，可在人类宿主的巨噬细胞中持续存在。改善结核病治疗的一种方法是使用巨噬细胞受体的配体将抗生素靶向递送至巨噬细胞。使用J774巨噬细胞系和腹膜巨噬细胞在体外研究了抗结核抗生素莫西沙星与羧甲基葡聚糖缀合物的抗结核活性。该缀合物的抗结核活性高于游离莫西沙星。结果表明，在结核病感染中向巨噬细胞靶向递送抗生素具有前景。
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