Achilihu G, Frishman W H, Landau A
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
J Clin Pharmacol. 1991 Aug;31(8):758-62. doi: 10.1002/j.1552-4604.1991.tb03773.x.
A limited number of ectoenzymes appear to be involved in the inactivation of circulating-regulatory peptides. Neutral endopeptidase 24.11, a metallopeptidase, is known to inactivate atrial natriuretic peptide (ANP), a substance with diuretic, natriuretic, and vasodilatory effects. Synthetic inhibitors of endopeptidase 24.11, which can prolong the activity of ANP, are currently available. These agents are being evaluated as possible innovative therapies for patients with hypertension and congestive heart failure.
有限数量的外切酶似乎参与循环调节肽的失活。中性内肽酶24.11是一种金属肽酶，已知它可使心房利钠肽（ANP）失活，ANP是一种具有利尿、利钠和血管舒张作用的物质。目前已有可延长ANP活性的内肽酶24.11合成抑制剂。这些药物正在作为高血压和充血性心力衰竭患者可能的创新疗法进行评估。
