N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801可抑制视交叉上核中Fos蛋白的光诱导。

Photic induction of Fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801.

作者信息

Abe H, Rusak B, Robertson H A

机构信息

Department of Psychology, Dalhousie University, Halifax, N.S., Canada.

出版信息

Neurosci Lett. 1991 Jun 10;127(1):9-12. doi: 10.1016/0304-3940(91)90881-s.

DOI:10.1016/0304-3940(91)90881-s

PMID:1831888

Abstract

Exposure of rodents to light can induce expression of a number of immediate-early genes, including c-fos, in cells of the suprachiasmatic nucleus (SCN), a dominant pacemaker in the mammalian circadian system. We examined the effects of pre-treatment with the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, on the induction of Fos-like immunoreactivity (Fos-lir) in cells in the hamster SCN. At doses of 3 and 5 mg/kg, MK-801 treatment blocked photic induction of Fos-lir in the rostral SCN and ventrolateral portions of the caudal SCN but failed to block induction of Fos-lir in a discrete region of the dorsolateral SCN. These results suggest that photic induction of Fos-lir in most of the SCN depends on activation of an NMDA-type receptor which is sensitive to MK-801, but that Fos-lir in one portion of the SCN is induced by a mechanism which is not antagonized by MK-801.

摘要

将啮齿动物暴露于光照下可诱导包括c-fos在内的多种即早基因在视交叉上核（SCN）的细胞中表达，视交叉上核是哺乳动物昼夜节律系统中的主要起搏器。我们研究了用非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801预处理对仓鼠视交叉上核细胞中Fos样免疫反应性（Fos-lir）诱导的影响。在3和5mg/kg的剂量下，MK-801处理可阻断视交叉上核前部和视交叉上核尾部腹外侧部分中Fos-lir的光诱导，但未能阻断视交叉上核背外侧离散区域中Fos-lir的诱导。这些结果表明，视交叉上核大部分区域中Fos-lir的光诱导依赖于对MK-801敏感的NMDA型受体的激活，但视交叉上核一部分区域中的Fos-lir是由一种不受MK-801拮抗的机制诱导的。