Yosipovitch Gil, Samuel Lena S
Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Dermatol Ther. 2008 Jan-Feb;21(1):32-41. doi: 10.1111/j.1529-8019.2008.00167.x.
Neuropathic and psychogenic itch are two entities that have not been well studied. Neuropathic itch is related to pathology located at any point along the afferent pathway of the nervous system. It could be related to damage to the peripheral nervous system, such as in postherpetic neuropathy, brachioradial pruritus, notalgia paresthetica, and in central nervous system damage as a result of spinal cord tumors and demyelinization diseases such as multiple sclerosis. It has many clinical features similar to neuropathic pain. Patients complain of itch, which coincides with burning sensation, aching, and stinging. Psychogenic itch is related to psychologic abnormalities e.g., itch in obsessive compulsive disorders, depression, and delusions of parasitosis. Although no controlled studies have been conducted for treatment of neuropathic and psychogenic itch, medications that are part of the treatment armentarium for neuropathic pain, depression, and anxiety seem to be effective.
神经性瘙痒和心因性瘙痒是两个尚未得到充分研究的实体。神经性瘙痒与神经系统传入通路中任何一点的病理状态有关。它可能与周围神经系统损伤有关，如在带状疱疹后神经痛、臂桡侧瘙痒症、感觉异常性背痛中，也可能与脊髓肿瘤和脱髓鞘疾病（如多发性硬化症）导致的中枢神经系统损伤有关。它有许多与神经性疼痛相似的临床特征。患者主诉瘙痒，同时伴有烧灼感、疼痛和刺痛感。心因性瘙痒与心理异常有关，例如在强迫症、抑郁症和寄生虫妄想症中的瘙痒。虽然尚未进行关于治疗神经性和心因性瘙痒的对照研究，但用于治疗神经性疼痛、抑郁症和焦虑症的药物似乎有效。
