Zhang Tao, Song Zhexian, Chen Hong, Yu Xuehai, Jiang Zhengsheng
Department of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing, P. R. China.
J Biomater Sci Polym Ed. 2008;19(4):509-24. doi: 10.1163/156856208783719464.
By sequential ring-opening polymerization of ethylene oxide and epsilon-caprolactone, poly(ethylene oxide) (PEO)-poly(epsilon-caprolactone) (PCL) di-block co-polymers with a phosphoryl choline (PC)-terminated group were synthesized. Using FT-IR, NMR, DSC and SEC, the products were characterized and the results proved the successful synthesis of functionalized di-block co-polymer. After blending the products with polyurethane (PU) and casting the result as film, the PEO segments migrated to the surface of the blend and the PCL segments acted as an anchor to fix the co-polymer on PU matrix, while the PEO segments provided PU the hydrophibility to prevent the fibrinogen adsorption on PU. This specific di-block co-polymer and the method of processing are hoped to be applied in the biomedical field to improve the biocompatibility of polymer materials.
通过环氧乙烷和ε-己内酯的顺序开环聚合，合成了具有磷酰胆碱（PC）封端基团的聚环氧乙烷（PEO）-聚ε-己内酯（PCL）二嵌段共聚物。利用傅里叶变换红外光谱（FT-IR）、核磁共振（NMR）、差示扫描量热法（DSC）和尺寸排阻色谱法（SEC）对产物进行了表征，结果证明成功合成了功能化二嵌段共聚物。将产物与聚氨酯（PU）共混并流延成膜后，PEO链段迁移到共混物表面，PCL链段作为锚定物将共聚物固定在PU基体上，而PEO链段赋予PU亲水性以防止纤维蛋白原吸附在PU上。希望这种特定的二嵌段共聚物及其加工方法能够应用于生物医学领域，以提高高分子材料的生物相容性。
