Sánchez-Vázquez Rene, Briseño-Rodríguez G, Cardona-Muñoz Ernesto German, Gálvez-Gastélum Francisco Javier, Totsuka-Sutto Silvia Elena, Garcia-Benavides Leonel
Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara, Guadalajara, Jalisco, Mexico.
Angiology. 2008 Feb-Mar;59(1):64-71. doi: 10.1177/0003319707303700.
Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement.
静脉溃疡是腿部溃疡最常见的形式，由于受损皮肤上沉积物质的流失而引发病变。硝酸异山梨酯是一种血管扩张剂，对动脉和静脉均有作用，可促使血管层开放。目的是研究硝酸异山梨酯喷雾剂对慢性静脉溃疡患者的影响。45例患有慢性静脉溃疡的男女患者被随机分组，每天接受硝酸异山梨酯或安慰剂喷雾治疗，为期3个月。治疗期间每15天测量溃疡情况并记录临床特征。与接受安慰剂治疗的患者（54.35%）相比，接受硝酸异山梨酯治疗的患者溃疡面积改善率为71.29%。组织病理学研究表明肥大和增生毛细血管数量增加。从宏观上看，硝酸异山梨酯治疗效果最佳，但仅在治疗的前6周。接受硝酸异山梨酯喷雾治疗的慢性静脉溃疡患者病情有所改善。
