病毒和细胞因子在卡波西肉瘤相关疱疹病毒发病机制中的作用。
Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis.
作者信息
Gasperini Paola, Sakakibara Shuhei, Tosato Giovanna
机构信息
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
出版信息
J Leukoc Biol. 2008 Oct;84(4):994-1000. doi: 10.1189/jlb.1107777.
Abstract
Kaposi's sarcoma (KS)-associated herpesvirus is associated with the proliferative/malignant disorders KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD) in patients with AIDS. In spite of recent advances in the treatment of KS, PEL and MCD represent therapeutic challenges. Recent advances in dissecting the pathogenesis of these diseases have indicated that the viral cytokine IL-6 and the cellular cytokines/growth factors IL-10, IL-6, stromal cell-derived factor 1, and vascular endothelial growth factor are important contributors to the growth, survival, and spread of PEL and MCD and are therefore potential targets for drug development.
摘要
卡波西肉瘤相关疱疹病毒与艾滋病患者的增殖性/恶性疾病卡波西肉瘤、原发性渗出性淋巴瘤（PEL）和多中心Castleman病（MCD）相关。尽管最近在卡波西肉瘤的治疗方面取得了进展，但PEL和MCD仍面临治疗挑战。在剖析这些疾病发病机制方面的最新进展表明，病毒细胞因子白细胞介素-6以及细胞细胞因子/生长因子白细胞介素-10、白细胞介素-6、基质细胞衍生因子1和血管内皮生长因子是PEL和MCD生长、存活及扩散的重要促成因素，因此是药物研发的潜在靶点。
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