Hanyu Haruo, Sato Tomohiko, Akai Tomotaka, Shimizu Soichiro, Hirao Kentaro, Kanetaka Hidekazu, Iwamoto Toshihiko, Koizumi Kiyoshi
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
Dement Geriatr Cogn Disord. 2008;25(4):347-53. doi: 10.1159/000119594. Epub 2008 Mar 5.
BACKGROUND/AIMS: To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD).
We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method.
Statistical maps demonstrated a more extensive and severe reduction in perfusion in the unaware group than in the aware group. Quantitative analysis demonstrated a significant difference between the groups in the right subcallosal, anterior cingulate and cingulate gyri and left orbital, subcallosal, and anterior cingulate gyri.
Functional damage to the inferior, medial and orbital frontal lobes as well as the anterior cingulate gyri may be associated with the lack of awareness in patients with early AD.
背景/目的：探讨早期阿尔茨海默病（AD）患者记忆缺陷无意识状态的神经解剖学基础。
我们比较了有记忆缺陷意识的AD患者（n = 19）和无记忆缺陷意识的AD患者（n = 19）之间的局部灌注缺损情况。采用统计脑成像方法分析单光子发射计算机断层扫描（SPECT）数据。
统计图显示，无记忆缺陷意识组的灌注减少比有记忆缺陷意识组更广泛、更严重。定量分析表明，两组在右侧胼胝体下、前扣带回和扣带回以及左侧眶额、胼胝体下和前扣带回存在显著差异。
额叶下部、内侧和眶部以及前扣带回的功能损害可能与早期AD患者缺乏意识有关。
