Lee Dukgyu, Jung Sunki, Ryu Jungmin, Ahnn Joohong, Ha Ilho
IBST/Graduate Program in Neuroscience, Inje University, Busan 614-735, Korea.
Mol Cells. 2008 Feb 29;25(1):50-4.
The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
囊泡谷氨酸转运体（VGLUT）将谷氨酸转运到突触前囊泡中。在人类中已鉴定出三种VGLUT亚型，但其功能差异在很大程度上仍不清楚。EAT-4是秀丽隐杆线虫中人类VGLUT的唯一同源物。在此我们报告，eat-4突变体表现出过度觅食行为，并且人类VGLUT的每种亚型都能在功能上挽救eat-4蠕虫的缺陷。
