[用屋尘（HD）变应原进行支气管激发试验（BPT）后血浆β-血小板球蛋白（β-TG）、血小板因子4（PF4）和血栓素B2（TXB2）的变化]

[The changes in plasma beta-thromboglobulin (beta-TG), platelet factor 4 (PF4) and thromboxane B2 (TXB2) after a bronchial provocation test (BPT) with house dust (HD) allergen].

作者信息

Mizuno M, Adachi M, Maruyama S, Suganuma T, Okada T, Takahashi T

机构信息

First Department of Internal Medicine, School of Medicine, Showa University.

出版信息

Arerugi. 1991 May;40(5):500-5.

PMID:1831967

Abstract

In order to investigate the role of platelets in allergic asthma, the time related changes in plasma levels of beta-TG, PF4 and TXB2 were evaluated following BPT with HD in 19 patients with bronchial asthma who were positive in skin test and RAST to HD. The results obtained were as follows. 1) Plasma beta-TG and PF4 levels tended to increase following BPT with HD at the time of immediate asthmatic response (IAR) in patients showing IAR alone. 2) Plasma beta-TG and PF4 levels increased significantly (p less than 0.05) at IAR and tended to increase at the time of late asthmatic response (LAR) in patients showing a dual asthmatic response (DAR). 3) The levels of plasma TXB2 in patients showing IAR alone significantly increased at IAR (p less than 0.05) and gradually decreased and the levels of plasma TXB2 in patients showing a DAR increased in each period of IAR, 3 hr after BPT and LAR, and the peak of TXB2 was observed in 3 hours after BPT. 4) These results suggest that platelets are activated at IAR and there was also a possible activation in platelets at LAR.

摘要

为了研究血小板在过敏性哮喘中的作用，对19名皮肤试验和放射性过敏原吸附试验（RAST）对屋尘（HD）呈阳性的支气管哮喘患者进行HD支气管激发试验（BPT）后，评估血浆β-血小板球蛋白（β-TG）、血小板第4因子（PF4）和血栓素B2（TXB2）水平的时间相关变化。得到的结果如下。1）仅表现为速发型哮喘反应（IAR）的患者在IAR时进行HD BPT后，血浆β-TG和PF4水平有升高趋势。2）表现为双相哮喘反应（DAR）的患者在IAR时血浆β-TG和PF4水平显著升高（p小于0.05），在迟发型哮喘反应（LAR）时趋于升高。3）仅表现为IAR的患者血浆TXB2水平在IAR时显著升高（p小于0.05），然后逐渐下降；表现为DAR的患者血浆TXB2水平在IAR、BPT后3小时和LAR的各个阶段均升高，TXB2峰值出现在BPT后3小时。4）这些结果表明血小板在IAR时被激活，在LAR时血小板也可能被激活。