Sasaki Miwa, Sakano Shigeru, Okayama Naoko, Akao Jumpei, Hara Tomohiko, Kawai Yoshihisa, Ohmi Chietaka, Hinoda Yuji, Naito Katsusuke
Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Neoplasia. 2008 Mar;10(3):255-65. doi: 10.1593/neo.07982.
Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the associations between functional polymorphisms in five DNA repair genes, and the prognosis of UUT-TCC in 103 UUT-TCC patients. Variant alleles in xeroderma pigmentosum complementation group C, more than three total variant alleles in all DNA repair genes studied and more than two total variant alleles in three nucleotide excision repair genes were independently associated with improved overall and disease-specific survival of UUT-TCC patients in multivariate analysis (P = .0063 and P = .0005 for xeroderma pigmentosum complementation group C, P = .016 and P = .0016 for all genes, and P = .0053 and P = .018 for nucleotide excision repair genes, respectively). These results suggest that some DNA repair gene polymorphisms may preoperatively be valuable as prognostic factors for UUT-TCC beyond tumor stage and grade, helping to provide optimal treatment strategies for individual patients.
上尿路移行细胞癌（UUT-TCC）是一种相当罕见的疾病，无论肿瘤分期如何，其预后在个体之间存在差异。据报道，DNA修复基因多态性会导致修复能力的调节，并可能影响UUT-TCC的预后。我们研究了103例UUT-TCC患者中五个DNA修复基因的功能多态性与UUT-TCC预后之间的关联。在多变量分析中，着色性干皮病C互补组中的变异等位基因、所研究的所有DNA修复基因中总共三个以上的变异等位基因以及三个核苷酸切除修复基因中总共两个以上的变异等位基因与UUT-TCC患者总体生存率和疾病特异性生存率的提高独立相关（着色性干皮病C互补组分别为P = 0.0063和P = 0.0005，所有基因分别为P = 0.016和P = 0.0016，核苷酸切除修复基因分别为P = 0.0053和P = 0.018）。这些结果表明，一些DNA修复基因多态性术前可能作为UUT-TCC预后因素具有价值，超越肿瘤分期和分级，有助于为个体患者提供最佳治疗策略。
