延髓背侧注射心钠素可兴奋迷走传出神经并抑制胃蠕动。
Dorsal medullary injection of atrial natriuretic factor (ANF) excites vagal efferents and inhibits gastric motility.
作者信息
McCann M J, Nice-Lepard K, Rogers R C
机构信息
Department of Physiology, Ohio State University College of Medicine, Columbus, 43210.
出版信息
Brain Res. 1991 May 24;549(2):247-52. doi: 10.1016/0006-8993(91)90464-7.
Atrial natriuretic factor (ANF)-immunoreactive fibers are found in the dorsal motor nucleus of the vagus (DMN) along with receptors for that peptide. Previous investigations showed that ANF injections into the DMN did not influence cardiovascular functions. Since the DMN is largely (but not exclusively) involved with the control of gastrointestinal functions, we hypothesized that ANF may act on gastric, rather than cardiovascular vagal efferents. Injections of ANF (20 pmol rat atriopeptin III in 20 nl) into the DMN evoked a vagally dependent reduction in gastric motility. In a separate electrophysiological study, 10 of 15 (66%) antidromically identified DMN neurons were excited by micropressure-applied ANF (25-500 fmol in 50-1000 pl). We propose that ANF-containing neurons in the DMN reduce gastric motility by activating vagal efferents that synapse with inhibitory neurons in the gastric enteric nervous system.
在迷走神经背核（DMN）中发现了心房钠尿肽（ANF）免疫反应性纤维以及该肽的受体。先前的研究表明，向DMN注射ANF不会影响心血管功能。由于DMN在很大程度上（但并非唯一）参与胃肠功能的控制，我们推测ANF可能作用于胃迷走传出神经，而非心血管迷走传出神经。向DMN注射ANF（20 nl中含20 pmol大鼠心房肽III）可引起依赖迷走神经的胃动力降低。在另一项电生理研究中，15个经逆向鉴定的DMN神经元中有10个（66%）被微压施加的ANF（50 - 1000 pl中含25 - 500 fmol）兴奋。我们提出，DMN中含ANF的神经元通过激活与胃肠神经系统中抑制性神经元形成突触的迷走传出神经来降低胃动力。
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