1-(3,5-二芳基-4,5-二氢-1H-吡唑-4-基)-1H-咪唑衍生物的抗真菌和抗分枝杆菌活性
Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives.
作者信息
Zampieri Daniele, Mamolo Maria Grazia, Laurini Erik, Scialino Giuditta, Banfi Elena, Vio Luciano
机构信息
Department of Pharmaceutical Sciences, Piazzale Europa 1, University of Trieste, I-34127 Trieste, Italy.
出版信息
Bioorg Med Chem. 2008 Apr 15;16(8):4516-22. doi: 10.1016/j.bmc.2008.02.055. Epub 2008 Feb 21.
1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.
合成了1-(3,5-二芳基-4,5-二氢-1H-吡唑-4-基)-1H-咪唑衍生物，并对其体外抗真菌和抗分枝杆菌活性进行了测试。这些咪唑衍生物对白色念珠菌临床菌株表现出优异的抗真菌活性，对结核分枝杆菌H(37)Rv参考菌株表现出有趣的抗结核活性。
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