Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assuit 71524, Egypt.
Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
Molecules. 2021 Aug 18;26(16):4995. doi: 10.3390/molecules26164995.
Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated derivatives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.
吡唑类化合物被认为是药物化学中的重要结构片段。之前的综述讨论了吡唑类化合物的重要性及其生物活性；然而，很少有综述涉及杂环稠合衍生物的化学和生物学。因此，我们将重点放在截至 2020 年的吡唑类化合物及其杂环稠合衍生物的合成、应用以及作为生物活性基团的最新研究进展上。此外，我们还重点关注了吡唑类化合物合成中常用的传统方法。
