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动脉损伤修复过程中转化生长因子β1的产生。

Production of transforming growth factor beta 1 during repair of arterial injury.

作者信息

Majesky M W, Lindner V, Twardzik D R, Schwartz S M, Reidy M A

机构信息

Department of Pathology, University of Washington, Seattle 98195.

出版信息

J Clin Invest. 1991 Sep;88(3):904-10. doi: 10.1172/JCI115393.

DOI:10.1172/JCI115393
PMID:1832175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC295478/
Abstract

Repair of arterial injury produced by balloon angioplasty leads to the formation of a neointima and a narrowing of the vascular lumen. In this study, we examined the possibility that smooth muscle cells (SMC) in injured rat carotid arteries are stimulated to produce type-1 transforming growth factor-beta (TGF-beta 1) during neointima formation in vivo. Levels of TGF-beta 1 transcripts (2.4 kb) were significantly increased within 6 h after carotid injury and reached a maximum (five to sevenfold) by 24 h. Regenerating left carotids had sustained increases in TGF-beta 1 mRNA levels (about fivefold) over the next 2 wk, during which time a substantial neointimal thickening was formed. No changes in basal TGF-beta 1 mRNA levels were found in contralateral uninjured carotids at any of the times examined. Immunohistochemical studies showed that a large majority of neointimal SMC were stained for TGF-beta 1 protein in an intracellular pattern, consistent with active TGF-beta 1 synthesis in this tissue. Neointima formation and TGF-beta 1 immunoreactivity were correlated with increases in fibronectin, collagen alpha 2(I), and collagen alpha 1(III) gene expression. Infusion of purified, recombinant TGF-beta 1 into rats with a preexisting neointima produced a significant stimulation of carotid neointimal SMC DNA synthesis. These results suggest that TGF-beta 1 plays an important role as an endogenous growth regulatory factor produced by neointimal SMC themselves during progressive neointimal thickening after balloon angioplasty.

摘要

球囊血管成形术所致动脉损伤的修复会导致新生内膜形成和血管腔狭窄。在本研究中，我们检测了在体内新生内膜形成过程中，损伤大鼠颈动脉中的平滑肌细胞（SMC）是否会被刺激产生1型转化生长因子-β（TGF-β1）。TGF-β1转录本（2.4 kb）水平在颈动脉损伤后6小时内显著升高，并在24小时时达到峰值（升高五至七倍）。在接下来的2周内，再生的左颈动脉中TGF-β1 mRNA水平持续升高（约五倍），在此期间形成了大量新生内膜增厚。在任何检测时间，对侧未损伤的颈动脉中基础TGF-β1 mRNA水平均未发现变化。免疫组织化学研究表明，绝大多数新生内膜SMC的TGF-β1蛋白呈细胞内染色模式，这与该组织中TGF-β1的活跃合成一致。新生内膜形成和TGF-β1免疫反应性与纤连蛋白、胶原α2（I）和胶原α1（III）基因表达的增加相关。向已有新生内膜的大鼠体内注入纯化的重组TGF-β1可显著刺激颈动脉新生内膜SMC的DNA合成。这些结果表明，TGF-β1作为一种内源性生长调节因子，在球囊血管成形术后新生内膜逐渐增厚过程中，由新生内膜SMC自身产生并发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/fa9307164802/jcinvest00062-0188-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/46fdcb51eb3f/jcinvest00062-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/331074055110/jcinvest00062-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/62c00f3a5103/jcinvest00062-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/fa9307164802/jcinvest00062-0188-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/46fdcb51eb3f/jcinvest00062-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/331074055110/jcinvest00062-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/62c00f3a5103/jcinvest00062-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/330f/295478/fa9307164802/jcinvest00062-0188-b.jpg

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2
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3
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J Adv Res. 2025 Jun;72:387-400. doi: 10.1016/j.jare.2024.07.004. Epub 2024 Jul 8.
4
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Animals (Basel). 2023 Jun 26;13(13):2112. doi: 10.3390/ani13132112.
5
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6
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4
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6
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