Belmar-Lopez Carolina, Mancheno-Corvo Pablo, Saornil Maria Antonia, Baril Patrick, Vassaux Georges, Quintanilla Miguel, Martin-Duque Pilar
Universidad Francisco de Vitoria, Facultad de Ciencias Biosanitarias, Dpto. Biotecnología, Pozuelo de Alarcón, Madrid, Spain.
Clin Transl Oncol. 2008 Mar;10(3):137-42. doi: 10.1007/s12094-008-0170-4.
Melanoma is a malignant tumour derived from melanocytes (dendritic cells originated from the neural crest and capable to produce melanin synthesis) that could be established on the skin or less frequently on the uvea. The cellular origin from both kind of melanoma seems to be the same but the melanocytes migrates to the epithelia for cutaneous melanoma, while for uveal melanoma, they migrate to mesodermic tissues. Despite the common origin, both melanomas show extreme differences in their metastatic potential, clinical response to treatments, immune response and genetic alterations. We will describe some of those differences in this review.
黑色素瘤是一种源自黑素细胞（起源于神经嵴的树突状细胞，能够产生黑色素合成）的恶性肿瘤，可发生于皮肤，较少见于葡萄膜。两种黑色素瘤的细胞起源似乎相同，但皮肤黑色素瘤的黑素细胞迁移至上皮组织，而葡萄膜黑色素瘤的黑素细胞则迁移至中胚层组织。尽管起源相同，但两种黑色素瘤在转移潜能、对治疗的临床反应、免疫反应和基因改变方面存在极大差异。我们将在本综述中描述其中一些差异。
