Does antisense make sense of AID targeting?
作者信息
Roa Sergio, Kuang Fei Li, Scharff Matthew D
机构信息
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3661-2. doi: 10.1073/pnas.0800935105. Epub 2008 Mar 5.
Abstract
摘要
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本文引用的文献
1
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.来自免疫球蛋白重链基因座V(D)J和转换区的反义转录本。
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3843-8. doi: 10.1073/pnas.0712291105. Epub 2008 Feb 21.
2
Immunoglobulin somatic hypermutation.免疫球蛋白体细胞超突变
Annu Rev Genet. 2007;41:107-20. doi: 10.1146/annurev.genet.41.110306.130340.
3
AID-initiated purposeful mutations in immunoglobulin genes.由活化诱导的胞苷脱氨酶引发的免疫球蛋白基因的定向突变。
Adv Immunol. 2007;94:127-55. doi: 10.1016/S0065-2776(06)94005-X.
4
Targeting of AID to immunoglobulin genes.
Adv Exp Med Biol. 2007;596:83-91. doi: 10.1007/0-387-46530-8_8.
5
Molecular mechanisms of antibody somatic hypermutation.抗体体细胞超突变的分子机制。
Annu Rev Biochem. 2007;76:1-22. doi: 10.1146/annurev.biochem.76.061705.090740.
6
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.在靶向体细胞高频突变区域检测与染色质相关的单链DNA
J Exp Med. 2007 Jan 22;204(1):181-90. doi: 10.1084/jem.20062032. Epub 2007 Jan 16.
7
Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspots.计算分析表明，A到G的突变与体细胞超突变热点处的新生mRNA发夹结构相关。
DNA Repair (Amst). 2006 Nov 8;5(11):1346-63. doi: 10.1016/j.dnarep.2006.06.002. Epub 2006 Aug 1.
8
Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops.活化诱导脱氨酶与类别转换区R环的可及性的精细结构分析。
Mol Cell Biol. 2005 Mar;25(5):1730-6. doi: 10.1128/MCB.25.5.1730-1736.2005.
9
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.当DNA处于超螺旋状态时，激活诱导的胞苷脱氨酶（AID）可靶向两条DNA链。
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12997-3002. doi: 10.1073/pnas.0404974101. Epub 2004 Aug 24.
10
Separate domains of AID are required for somatic hypermutation and class-switch recombination.体细胞高频突变和类别转换重组需要AID的不同结构域。
Nat Immunol. 2004 Jul;5(7):707-12. doi: 10.1038/ni1086. Epub 2004 Jun 13.
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