人类免疫缺陷病毒1型包膜的膜近端外部区域：抗体中和的主要位点及疫苗设计靶点。
The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design.
作者信息
Montero Marinieve, van Houten Nienke E, Wang Xin, Scott Jamie K
机构信息
Department of Molecular Biology and Chemistry, Simon Fraser University, 8888 University Drive, Burnaby V5A 1S6, British Columbia, Canada.
出版信息
Microbiol Mol Biol Rev. 2008 Mar;72(1):54-84, table of contents. doi: 10.1128/MMBR.00020-07.
Abstract
Enormous efforts have been made to produce a protective vaccine against human immunodeficiency virus type 1; there has been little success. However, the identification of broadly neutralizing antibodies against epitopes on the highly conserved membrane-proximal external region (MPER) of the gp41 envelope protein has delineated this region as an attractive vaccine target. Furthermore, emerging structural information on the MPER has provided vaccine designers with new insights for building relevant immunogens. This review describes the current state of the field regarding (i) the structure and function of the gp41 MPER; (ii) the structure and binding mechanisms of the broadly neutralizing antibodies 2F5, 4E10, and Z13; and (iii) the development of an MPER-targeting vaccine. In addition, emerging approaches to vaccine design are presented.
摘要
人们已经付出了巨大努力来研发针对1型人类免疫缺陷病毒的保护性疫苗，但成效甚微。然而，针对gp41包膜蛋白高度保守的膜近端外部区域（MPER）表位的广泛中和抗体的鉴定，已将该区域确定为一个有吸引力的疫苗靶点。此外，关于MPER的新出现的结构信息为疫苗设计者构建相关免疫原提供了新的见解。本综述描述了该领域的当前状况，涉及（i）gp41 MPER的结构和功能；（ii）广泛中和抗体2F5、4E10和Z13的结构和结合机制；以及（iii）靶向MPER的疫苗的研发。此外，还介绍了疫苗设计的新出现的方法。
相似文献
1
The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design.
Microbiol Mol Biol Rev. 2008 Mar;72(1):54-84, table of contents. doi: 10.1128/MMBR.00020-07.
2
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.
J Virol. 2005 Jan;79(2):1252-61. doi: 10.1128/JVI.79.2.1252-1261.2005.
3
Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles.
Virology. 2008 Mar 30;373(1):72-84. doi: 10.1016/j.virol.2007.11.005. Epub 2007 Dec 26.
4
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
J Virol. 2007 Apr;81(8):4033-43. doi: 10.1128/JVI.02588-06. Epub 2007 Feb 7.
5
N-terminal residues of an HIV-1 gp41 membrane-proximal external region antigen influence broadly neutralizing 2F5-like antibodies.
Virol Sin. 2015 Dec;30(6):449-56. doi: 10.1007/s12250-015-3664-6. Epub 2015 Dec 21.
6
Induction of neutralizing antibody against human immunodeficiency virus type 1 (HIV-1) by immunization with gp41 membrane-proximal external region (MPER) fused with porcine endogenous retrovirus (PERV) p15E fragment.
Vaccine. 2006 Jan 23;24(4):435-42. doi: 10.1016/j.vaccine.2005.08.006. Epub 2005 Aug 18.
7
Lipid modulation of membrane-bound epitope recognition and blocking by HIV-1 neutralizing antibodies.
FEBS Lett. 2008 Nov 12;582(27):3798-804. doi: 10.1016/j.febslet.2008.10.012. Epub 2008 Oct 16.
8
Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.
PLoS One. 2015 Jun 18;10(6):e0128562. doi: 10.1371/journal.pone.0128562. eCollection 2015.
9
The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects.
Protein Cell. 2018 Jul;9(7):596-615. doi: 10.1007/s13238-018-0534-7. Epub 2018 Apr 17.
10
The broadly neutralizing anti-human immunodeficiency virus type 1 4E10 monoclonal antibody is better adapted to membrane-bound epitope recognition and blocking than 2F5.
J Virol. 2008 Sep;82(18):8986-96. doi: 10.1128/JVI.00846-08. Epub 2008 Jul 2.
引用本文的文献
1
The evolution of envelope function during coinfection with phylogenetically distinct human immunodeficiency virus.
BMC Infect Dis. 2024 Sep 9;24(1):934. doi: 10.1186/s12879-024-09805-z.
2
Chimeric vaccine design against the conserved TonB-dependent receptor-like β-barrel domain from the outer membrane tbpA and hpuB proteins of ATCC 23330.
Front Mol Biosci. 2023 Nov 20;10:1258834. doi: 10.3389/fmolb.2023.1258834. eCollection 2023.
3
Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice.
Vaccines (Basel). 2022 Dec 21;11(1):15. doi: 10.3390/vaccines11010015.
4
Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies.
J Virol. 2023 Jan 31;97(1):e0164722. doi: 10.1128/jvi.01647-22. Epub 2022 Dec 21.
5
A large HIV gp41 construct with trimer-of-hairpins structure exhibits V2E mutation-dominant attenuation of vesicle fusion and helicity very similar to V2E attenuation of HIV fusion and infection and supports: (1) hairpin stabilization of membrane apposition with larger distance for V2E; and (2) V2E dominance by an antiparallel β sheet with interleaved fusion peptide strands from two gp41 trimers.
Biophys Chem. 2023 Feb;293:106933. doi: 10.1016/j.bpc.2022.106933. Epub 2022 Nov 24.
6
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
Commun Biol. 2022 Nov 18;5(1):1265. doi: 10.1038/s42003-022-04219-6.
7
The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay.
Int J Mol Sci. 2022 Jan 7;23(2):641. doi: 10.3390/ijms23020641.
8
A Comprehensive Analysis of Human Endogenous Retroviruses HERV-K (HML.2) from Teratocarcinoma Cell Lines and Detection of Viral Cargo in Microvesicles.
Int J Mol Sci. 2021 Nov 17;22(22):12398. doi: 10.3390/ijms222212398.
9
Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding.
J Clin Pediatr Neonatol. 2021;1(1):9-20. doi: 10.46439/pediatrics.1.003.
10
Small-Molecule Inhibition of Viral Fusion Glycoproteins.
Annu Rev Virol. 2021 Sep 29;8(1):459-489. doi: 10.1146/annurev-virology-022221-063725. Epub 2021 Jul 1.
本文引用的文献
1
A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120.
FASEB J. 2008 May;22(5):1380-92. doi: 10.1096/fj.07-8983com. Epub 2008 Jan 15.
2
Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection.
J Virol. 2008 Jan;82(1):115-25. doi: 10.1128/JVI.00927-07. Epub 2007 Oct 17.
3
Fc receptor but not complement binding is important in antibody protection against HIV.
Nature. 2007 Sep 6;449(7158):101-4. doi: 10.1038/nature06106.
4
Structural analysis and in vivo administration of an anti-idiotypic antibody against mAb 2F5.
Mol Immunol. 2008 Feb;45(4):1027-34. doi: 10.1016/j.molimm.2007.07.030. Epub 2007 Sep 4.
5
The influence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers.
FEBS J. 2007 Oct;274(19):5096-104. doi: 10.1111/j.1742-4658.2007.06029.x. Epub 2007 Sep 4.
6
Antibodies generated in cats by a lipopeptide reproducing the membrane-proximal external region of the feline immunodeficiency virus transmembrane enhance virus infectivity.
Clin Vaccine Immunol. 2007 Aug;14(8):944-51. doi: 10.1128/CVI.00140-07. Epub 2007 Jun 27.
7
In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.
J Virol. 2007 Aug;81(16):8793-808. doi: 10.1128/JVI.00598-07. Epub 2007 Jun 13.
8
The binding of HIV-1 gp41 membrane proximal domain to its mucosal receptor, galactosyl ceramide, is structure-dependent.
Cell Calcium. 2008 Jan;43(1):73-82. doi: 10.1016/j.ceca.2007.04.011. Epub 2007 Jun 5.
9
Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion.
J Biol Chem. 2007 Aug 10;282(32):23104-16. doi: 10.1074/jbc.M703485200. Epub 2007 May 25.
10
Structure and plasticity of the human immunodeficiency virus gp41 fusion domain in lipid micelles and bilayers.
Biophys J. 2007 Aug 1;93(3):876-85. doi: 10.1529/biophysj.106.102335. Epub 2007 May 18.
Zotero 插件