Cuffini Silvia L, Faudone Sonia, Ferro Maribel, Garland María Teresa, Baggio Ricardo
Agencia Córdoba Ciencia, Córdoba, Argentina.
Acta Crystallogr C. 2008 Mar;64(Pt 3):o119-22. doi: 10.1107/S0108270107054443. Epub 2008 Feb 9.
The present 0.25-hydrated form of rosiglitazone maleate [systematic name: (+/-)-2-({2-[2,4-dioxo-1,3-thiazolidin-5-ylmethyl)phenoxy]ethyl}methylamino)pyridinium maleate 0.25-hydrate], C(18)H(20)N(3)O(3)S(+) x C(4)H(3)O(4)(-) x 0.25 H(2)O, is a racemate with two independent moieties in the unit cell. Although the cation geometry does not differ substantially from that in the previously reported hydrochloride, the packing is quite different, the main feature being the formation of hydrogen-bonded tetramers, linked head-to-tail into weakly interacting chains.
马来酸罗格列酮的现有0.25水合物形式[系统名称：(+/-)-2-({2-[2,4-二氧代-1,3-噻唑烷-5-基甲基)苯氧基]乙基}甲基氨基)吡啶鎓马来酸盐0.25水合物]，C(18)H(20)N(3)O(3)S(+)×C(4)H(3)O(4)(-)×0.25 H(2)O，是一种在晶胞中有两个独立部分的外消旋体。尽管阳离子几何结构与先前报道的盐酸盐中的结构没有实质性差异，但堆积方式却大不相同，主要特征是形成了氢键连接的四聚体，这些四聚体头对尾连接成弱相互作用的链。
