载脂蛋白Eε4等位基因与轻度认知功能障碍进展期脑萎缩增加相关：基于体素的形态学研究。
Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.
作者信息
Hämäläinen A, Grau-Olivares M, Tervo S, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala E-L, Nissinen A, Vanninen R L, Soininen H
机构信息
Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio, Finland.
出版信息
Neurodegener Dis. 2008;5(3-4):186-9. doi: 10.1159/000113698. Epub 2008 Mar 6.
BACKGROUND
The apolipoprotein E (APOE) epsilon4 allele is a risk factor for Alzheimer's disease. Earlier studies have shown differences in brain structure according to the APOE epsilon4 status.
OBJECTIVE
To assess possible differences in brain structure according to the APOE epsilon4 status in mild cognitive impairment (MCI) subjects in relation to conversion to dementia.
METHODS
In a follow-up study of 56 MCI subjects, 13 MCI subjects progressed to dementia (PMCI) during a mean follow-up time of 31 months. Brain structure differences in both stable MCI (SMCI) and PMCI epsilon4 carriers and noncarriers in the baseline MRI scan were assessed with voxel-based morphometry.
RESULTS
The SMCI epsilon4 carriers had atrophy in the amygdala and hippocampus compared to the SMCI noncarriers. The PMCI epsilon4 carriers revealed atrophy of the left inferior frontal gyrus and parietal cortex compared to the PMCI noncarriers.
CONCLUSION
The rate of brain atrophy in certain brain areas may be increased in epsilon4-positive MCI subjects progressing to dementia.
背景
载脂蛋白E（APOE）ε4等位基因是阿尔茨海默病的一个风险因素。早期研究表明，根据APOE ε4状态，脑结构存在差异。
目的
评估轻度认知障碍（MCI）患者中，根据APOE ε4状态，在向痴呆转化方面脑结构可能存在的差异。
方法
在一项对56名MCI患者的随访研究中，13名MCI患者在平均31个月的随访期内进展为痴呆（PMCI）。采用基于体素的形态测量法评估基线MRI扫描中稳定MCI（SMCI）和PMCI的ε4携带者与非携带者的脑结构差异。
结果
与SMCI非携带者相比，SMCI的ε4携带者杏仁核和海马体萎缩。与PMCI非携带者相比，PMCI的ε4携带者左侧额下回和顶叶皮质萎缩。
结论
进展为痴呆的ε4阳性MCI患者某些脑区的脑萎缩率可能会增加。
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