Dentico P, Zavoianni A, Volpe A, Buongiorno R, Palma R, Calasso A, Pastore G, Schiraldi O
Istituto Policattedra Clinica Medica e Malattie Infettive dell'Università degli Studi di Bari, Italy.
Vaccine. 1991 Jun;9(6):438-42. doi: 10.1016/0264-410x(91)90132-p.
To establish the epidemiology of viral hepatitis B (HBV) infection in hospital staff the sera of 2462 workers and 176 professional nursing students were examined. The prevalences of HBsAg and anti-HBs among the workers were 4.5 and 42.2% and among the students were 2.3 and 15.3%, respectively. The risk of infection showed a correlation with the profession of the hospital workers, the various jobs carried out in different departments, age, and the number of working years. The anti-hepatitis vaccination with HBVax and HEVAC-B vaccines was used on 142 professional students and 996 hospital workers. Five years after the beginning of the vaccine cycle the percentage of responders observed among the students was 75 (HBVax) and 79% (HEVAC-B). Among the hospital staff the response registered was 66 and 71%, respectively. The best recorded response among the youngest subjects suggests that the anti-hepatitis vaccination should be obligatory for hospital workers at the beginning of their working period or professional training.
为了确定医院工作人员中乙型病毒性肝炎（HBV）感染的流行病学情况，对2462名工作人员和176名专业护理学生的血清进行了检测。工作人员中HBsAg和抗-HBs的流行率分别为4.5%和42.2%，学生中分别为2.3%和15.3%。感染风险与医院工作人员的职业、不同科室所从事的各种工作、年龄以及工作年限相关。142名专业学生和996名医院工作人员接种了HBVax和HEVAC-B乙肝疫苗。疫苗接种周期开始五年后，学生中观察到的应答者百分比分别为75%（HBVax）和79%（HEVAC-B）。医院工作人员中的应答率分别为66%和71%。最年轻受试者中记录到的最佳应答表明，应强制医院工作人员在工作初期或专业培训开始时接种乙肝疫苗。
