Danser A H Jan, Batenburg Wendy W, van Esch Joep H M, Krop Manne
Division of Vascular Pharmacology and Metabolism, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, Rotterdam, The Netherlands.
J Mol Med (Berl). 2008 Jun;86(6):655-8. doi: 10.1007/s00109-008-0318-2. Epub 2008 Mar 6.
For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.
多年来，血管紧张素原酶一直被认为仅仅是肾素的无活性前体。然而，在患有微血管并发症的糖尿病患者中其水平升高，以及它在身体各个部位的肾外产生，表明并非如此。本文综述了血管紧张素原酶的起源、调节和酶活性，其在肾素抑制过程中的作用，以及它与最近发现的（前）肾素受体结合所产生的依赖血管紧张素和不依赖血管紧张素的后果。综述最后提出了血管紧张素原酶而非肾素决定组织中血管紧张素生成的观点。
