García M E García, García A M García, Catalán M J
Departamento de Neurología, Hospital Clínico San Carlos, Madrid.
Neurologia. 2008 Mar;23(2):122-5.
Primary lymphoma of the central nervous system PLCNS) was a very uncommon disease until a few decades ago. However, its incidence has increased in recent years, mainly in immunocompetent patients. Thus, some authors suggest that PLCNS may become the most frequent tumor. The final diagnosis is based on the pathology study of the samples obtained with stereotaxic biopsy or with surgery, but X-ray studies may be very useful in the orientation of this disease. The typical finding in immunocompetent subjects is the appearance of single supratentorial lesions with homogeneous uptake of contrast and scarce edema, without edema, necrosis nor bleeding. Survival has increased thanks to the new treatments applied, although there is still controversy regarding frequency, dose and administration form of many of them. We present the case of an immunocompetent male patient with progressive dyplopia and vertigo caused by a primary lymphoma of the central nervous system and a review the literature.
直到几十年前，原发性中枢神经系统淋巴瘤（PLCNS）还是一种非常罕见的疾病。然而，近年来其发病率有所上升，主要发生在免疫功能正常的患者中。因此，一些作者认为PLCNS可能会成为最常见的肿瘤。最终诊断基于立体定向活检或手术获取的样本的病理研究，但X线检查在该病的定位中可能非常有用。免疫功能正常的患者的典型表现是幕上出现单个病变，造影剂摄取均匀，水肿轻微，无水肿、坏死或出血。由于采用了新的治疗方法，患者的生存率有所提高，尽管其中许多治疗方法在频率、剂量和给药方式方面仍存在争议。我们报告一例由原发性中枢神经系统淋巴瘤引起进行性复视和眩晕的免疫功能正常男性患者的病例，并对文献进行综述。
