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Synthesis and preliminary evaluation of aminoalkanol derivatives of selected azatricycloundecane system for binding with beta-adrenergic and 5HT1A and 5HT2A receptors.

作者信息

Kossakowski Jerzy, Kuran Bozena

机构信息

Department of Medical Chemistry, Medical University, 3 Oczki Str., 02-007 Warszawa, Poland.

出版信息

Acta Pol Pharm. 2007 Nov-Dec;64(6):527-33.

PMID:18323247
Abstract

A series of aminoalkanol derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)] undec-8-en-1-yl acetate and 1,11-dimethyl-4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione was prepared. The pharmacological profile of selected compounds was evaluated for affinity to beta-adrenoreceptors and serotoninergic receptors (5HT1A and 5HT2A).

摘要

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