利用人-中国仓鼠体细胞杂种对人类1号染色体上七个基因进行区域定位。I. 携带涉及1号染色体相互易位的人类细胞杂交后获得的结果。
Regional assignment of seven genes on chromosome 1 of man by use of man-Chinese hamster somatic cell hybrids. I. Results obtained after hybridization of human cells carrying reciprocal translocations involving chromosome 1.
作者信息
Jongsma A P, Burgerhout W G
出版信息
Cytogenet Cell Genet. 1977;18(5):255-66. doi: 10.1159/000130771.
Regional localization studies of genes coding for human PGD, PPH1, PGM1, UGPP, GuK1, Pep-C, and FH, which have been assigned to chromosome 1, were performed with man-Chinese hamster somatic cell hybrids, Informative hybrids that retained fragments of the human chromosome 1 were produced by fusion of hamster cells with human cells carrying reciprocal translocations involving chromosome 1. Analysis of the hybrids that retained one of the translocation chromosomes or de novo rearrangements involving the human 1 revealed the following gene positions: PGD and PPH1 in 1pter leads to 1p32, PGM1 in 1p32 leads to 1p22, UGPP and GuK1 in 1q21 leads to 1q42, FH in 1qter leads to 1q42, and Pep-C probably in 1q42.
对已定位到1号染色体上的编码人PGD、PPH1、PGM1、UGPP、GuK1、Pep-C和FH的基因进行了区域定位研究，使用人-中国仓鼠体细胞杂种进行。通过仓鼠细胞与携带涉及1号染色体的相互易位的人细胞融合，产生了保留人1号染色体片段的信息性杂种。对保留其中一条易位染色体或涉及人1号染色体的新生重排的杂种进行分析，揭示了以下基因位置：PGD和PPH1位于1pter至1p32，PGM1位于1p32至1p22，UGPP和GuK1位于1q21至1q42，FH位于1qter至1q42，Pep-C可能位于1q42。
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