Jin Di, Zhang Lianjun, Zheng Jialin, Zhao Yong
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Autoimmunity. 2008 Mar;41(2):154-62. doi: 10.1080/08916930701776605.
T helper cells (Th cells) are traditionally thought to differentiate into Th1 and Th2 subsets based on their cytokine profiles. Recently, a subset of interleukin (IL)-17-producing cells (Th17 cells) which develop and function in a distinct way from Th1 or Th2 cells has been identified. Th17 cells have been shown to play a crucial role in the induction of autoimmune tissue injuries, inflammation and infection. Studies on Th17 subset and its relevant issues offered potential therapeutic targets for patients with autoimmune diseases, cancer, infection and transplant, which may have significant impacts in the prevention and/or treatment of immunity-related diseases in clinics.
传统观点认为，辅助性T细胞（Th细胞）根据其细胞因子谱分化为Th1和Th2亚群。最近，已鉴定出一种产生白细胞介素（IL）-17的细胞亚群（Th17细胞），其发育和功能与Th1或Th2细胞不同。Th17细胞已被证明在自身免疫性组织损伤、炎症和感染的诱导中起关键作用。对Th17亚群及其相关问题的研究为自身免疫性疾病、癌症、感染和移植患者提供了潜在的治疗靶点，这可能对临床上免疫相关疾病的预防和/或治疗产生重大影响。
