双氯芬酸用于光化性角化病管理和治疗的安全性。
The safety of diclofenac for the management and treatment of actinic keratoses.
作者信息
Iraji Fariba, Siadat Amir Hossein, Asilian Ali, Enshaieh Shahla, Shahmoradi Zabiholah
机构信息
Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran.
出版信息
Expert Opin Drug Saf. 2008 Mar;7(2):167-72. doi: 10.1517/14740338.7.2.167.
BACKGROUND
Actinic keratoses (AKs), defined as carcinoma in situ of squamous carcinoma, is usually induced by excessive sun exposure. The efficacy of 3% diclofenac in 2.5% hyaluronic acid gel for treatment of AKs has been documented in a few studies.
OBJECTIVE
Is diclofenac safe and effective for the management and treatment of AKs?
METHOD
All the papers that were cited in Medline and ISI Web of Science are included in this study.
RESULTS/CONCLUSION: The use of diclofenac is associated with a few side effects, which include pruritus, rashes, dry skin, and scaling. These side effects are usually minimal and tolerable; therefore, this topical medication is suggested as the first line of treatment for AKs.
背景
光化性角化病（AKs）被定义为鳞状细胞癌的原位癌，通常由过度日晒引起。少数研究记录了3%双氯芬酸在2.5%透明质酸凝胶中治疗AKs的疗效。
目的
双氯芬酸用于AKs的管理和治疗是否安全有效？
方法
本研究纳入了Medline和ISI科学网中引用的所有论文。
结果/结论：使用双氯芬酸会产生一些副作用，包括瘙痒、皮疹、皮肤干燥和脱屑。这些副作用通常轻微且可耐受；因此，建议将这种局部用药作为AKs的一线治疗药物。
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