Miller G, Bertelli L, Little T, Guilmette R A
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Radiat Prot Dosimetry. 2007;127(1-4):361-9. doi: 10.1093/rpd/ncm470. Epub 2008 Mar 6.
Simulated-data internal dosimetry cases for use in intercomparison exercises or as a software verification and validation tool have been published on the internet (www.lanl.gov/bayesian/software Bayesian software package II). A user may validate their internal dosimetry code or method using this simulated bioassay data. Or, the user may choose to try out the Los Alamos National Laboratory codes ID and UF, which are also supplied. A Poisson-lognormal model of data uncertainty is assumed. A collection of different possible models for each nuclide (e.g. solubility types and particle sizes) are used. For example, for 238Pu, 14 different biokinetic models or types (8 inhalation, 4 wound and 2 ingestion) are assumed. Simulated data are generated for all the assumed biokinetic models, both for incidents, where the time of intake is known, and for non-incidents, where it is not. For the dose calculations, the route of intake, but not the biokinetic model, is considered to be known. The object is to correctly calculate the known true dose from simulated data covering a period of time. A 'correct' result has been defined in two ways: (1) that the credible limits of the calculated dose include the correct dose and (2) that the calculated dose is within a factor of 2 of the correct dose.
用于比对练习或作为软件验证与确认工具的模拟数据内照射剂量学案例已在互联网上发布(网址:www.lanl.gov/bayesian/software Bayesian software package II)。用户可以使用这些模拟生物测定数据来验证其内部剂量学代码或方法。或者,用户可以选择试用洛斯阿拉莫斯国家实验室提供的代码ID和UF。假定数据不确定性采用泊松对数正态模型。针对每种核素使用了一系列不同的可能模型(例如溶解度类型和颗粒大小)。例如,对于钚 - 238,假定有14种不同的生物动力学模型或类型(8种吸入、4种伤口沾染和2种摄入)。针对所有假定的生物动力学模型生成模拟数据,包括摄入时间已知的事故情况和摄入时间未知的非事故情况。对于剂量计算,假定摄入途径已知,但生物动力学模型未知。目标是根据涵盖一段时间的模拟数据正确计算已知的真实剂量。“正确”结果有两种定义方式:(1)计算剂量的可信区间包含正确剂量;(2)计算剂量在正确剂量的2倍范围内。