Sawada Kenichi, Hirokawa Makoto
Department of Internal Medicine III, Akita University Graduate School of Medicine.
Nihon Rinsho. 2008 Mar;66(3):505-11.
Aplastic anemia (AA) is a disorder characterized by the presence of pancytopenia and a hypocellular bone marrow. Acquired pure red cell aplasia (PRCA), a part of a unique form of AA, is a rare condition of profound anemia characterized by the absence of reticulocytes and the virtual absence of erythroid precursors in the bone marrow. AA can be effectively treated by either stem cell transplantation or immunosuppressive therapy. However, PRCA has so far been treated by several different regimens which are largely empirically selected since so little control data are available. This issue focuses on the current progress in the treatment of acquired AA and PRCA.
再生障碍性贫血（AA）是一种以全血细胞减少和骨髓细胞减少为特征的疾病。获得性纯红细胞再生障碍性贫血（PRCA）是AA的一种特殊形式，是一种罕见的严重贫血病症，其特征是无网织红细胞且骨髓中几乎没有红系前体细胞。AA可通过干细胞移植或免疫抑制疗法有效治疗。然而，迄今为止，PRCA的治疗采用了几种不同的方案，这些方案大多是根据经验选择的，因为可获得的对照数据非常少。本期聚焦于获得性AA和PRCA治疗的当前进展。
