Dan Kazuo
Department of Hematology, Nippon Medical School.
Nihon Rinsho. 2008 Mar;66(3):540-3.
Drug-induced anemia includes many kind of anemias with different mechanisms. Mechanisms of drug-induced anemia are divided into two groups, namely erythrocyte injury in peripheral blood and damage of erythroid progenitor cells or erythroblasts. Hemolytic anemias are included in the former and megaloblastic anemia, ringed sideroblastic anemia and pure red cell aplasia are included in the latter. When the drug induced anemia is suspected, complete blood cell count including reticulocyte count and examination of the blood smear and blood chemistry tests should be done. Also, history of the medication should be precisely taken. As for the treatment of drug-induced anemia, the responsible drug should be stopped immediately and individual therapy will be done if necessary.
药物性贫血包括多种机制不同的贫血。药物性贫血的机制分为两组，即外周血红细胞损伤和红系祖细胞或成红细胞损伤。前者包括溶血性贫血，后者包括巨幼细胞贫血、环形铁粒幼细胞贫血和纯红细胞再生障碍性贫血。当怀疑有药物性贫血时，应进行全血细胞计数（包括网织红细胞计数）、血涂片检查和血液化学检查。此外，应准确记录用药史。对于药物性贫血的治疗，应立即停用相关药物，必要时进行个体化治疗。
