Atkinson Charlotte, Newton Katherine M, Bowles Erin J Aiello, Yong Mellissa, Lampe Johanna W
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Am J Clin Nutr. 2008 Mar;87(3):679-87. doi: 10.1093/ajcn/87.3.679.
The soy isoflavone daidzein is metabolized to equol and O-desmethylangolensin (ODMA) by intestinal bacteria in approximately 30-50% and 80-90% of persons, respectively. Studies suggest beneficial health effects associated with daidzein-metabolizing phenotypes; thus, assessing their determinants is an important goal.
We evaluated relations between daidzein-metabolizing phenotypes and demographic, anthropometric, lifestyle, and dietary factors among premenopausal women in the United States.
Two hundred women provided a first-void urine sample after a 3-d soy challenge and completed a health and demographics questionnaire, physical activity questionnaire, food-frequency questionnaire, and 3-d food record. Urine samples were measured for isoflavones by gas chromatography-mass spectrometry to determine daidzein-metabolizing phenotypes.
Fifty-five (27.5%) and 182 (91%) women had detectable concentrations of urinary equol and ODMA (>87.5 ng/mL), respectively, and were classed as producers of these metabolites. Compared with nonproducers, equol producers were more likely (P < or = 0.05) to be Hispanic or Latino, to be highly educated, and to have frequent constipation, and ODMA producers were taller and less likely to be Asian than white. Equol and ODMA producers reported higher overall physical activity than did nonproducers.
We observed associations between equol production and ethnicity, education, constipation, and physical activity and between ODMA production and race, height, and physical activity. Associations with race and ethnicity were based on small numbers of Asian and Hispanic or Latino women, and confirmation of these findings is needed. Few dietary factors, assessed with the use of either a food-frequency questionnaire or food record, were associated with daidzein-metabolizing phenotypes.
大豆异黄酮黄豆苷元分别被肠道细菌代谢为雌马酚和O-去甲基安哥拉紫檀素（ODMA），在大约30% - 50%和80% - 90%的人群中出现这种情况。研究表明黄豆苷元代谢表型与有益健康效应相关；因此，评估其决定因素是一个重要目标。
我们评估了美国绝经前女性中黄豆苷元代谢表型与人口统计学、人体测量学、生活方式及饮食因素之间的关系。
200名女性在进行3天大豆激发试验后提供首次晨尿样本，并完成一份健康与人口统计学问卷、身体活动问卷、食物频率问卷以及3天食物记录。通过气相色谱 - 质谱法测量尿液样本中的异黄酮，以确定黄豆苷元代谢表型。
分别有55名（27.5%）和182名（91%）女性尿液中可检测到雌马酚和ODMA浓度（>87.5 ng/mL），并被归类为这些代谢产物的生产者。与非生产者相比，雌马酚生产者更有可能（P≤0.05）是西班牙裔或拉丁裔、受过高等教育且经常便秘，而ODMA生产者比白人更高且不太可能是亚洲人。雌马酚和ODMA生产者报告的总体身体活动水平高于非生产者。
我们观察到雌马酚产生与种族、教育程度、便秘及身体活动之间以及ODMA产生与种族、身高及身体活动之间存在关联。与种族和民族的关联基于少量亚洲及西班牙裔或拉丁裔女性，需要对这些发现进行验证。使用食物频率问卷或食物记录评估的饮食因素中，很少有与黄豆苷元代谢表型相关的。
