Al-Jaghbeer Eshraq, Khraisat Ahmad, Singh Sant P
Department of Internal Medicine, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 600064, USA.
J Cardiometab Syndr. 2008 Winter;3(1):40-4. doi: 10.1111/j.1559-4572.2008.06448.x.
The endocannabinoid system (ECS) is a neuroendocrine system that modulates several cardiometabolic processes. An overactive ECS is implicated as a significant contributor to the cardiometabolic syndrome and obesity, in addition to a large number of other physiologic processes. Endocannabinoid receptors have been detected centrally and peripherally, regulating appetite, food intake, metabolism, and storage. ECS blockade is thought to be a promising new pharmacologic modality of improving the unfavorable metabolic risk profile in patients with the cardiometabolic syndrome and obesity.
内源性大麻素系统（ECS）是一种调节多种心脏代谢过程的神经内分泌系统。除了大量其他生理过程外，过度活跃的ECS被认为是心脏代谢综合征和肥胖的重要促成因素。内源性大麻素受体已在中枢和外周被检测到，可调节食欲、食物摄入、新陈代谢和储存。ECS阻断被认为是改善心脏代谢综合征和肥胖患者不良代谢风险状况的一种有前景的新药物治疗方式。
