Koga T, Migita K, Miyashita T, Maeda Y, Nakamura M, Abiru S, Myoji M, Komori A, Yano K, Yatsuhashi H, Eguchi K, Ishibashi H
Clinical Research Center and Clinical Laboratory, NHO Nagasaki Medical Center, Omura, Japan.
Clin Exp Rheumatol. 2008 Jan-Feb;26(1):121-4.
To determine the frequency of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with HCV infection, primary biliary cirrhosis (PBC) and type-I autoimmune hepatitis (AIH) to assess the specificity of anti-CCP antibodies.
Rheumatoid factor (RF) and anti-CCP antibodies were measured in the sera from patients with HCV infection (n=45), PBC (n=73), AIH (n=55) and rheumatoid arthritis (n=48), and also from the sera of healthy subjects (n=23). Anti-CCP antibodies were measured using a second generation enzyme-linked immunosorbent assay (ELISA).
No sera with elevated anti-CCP were found in the patients with HCV infection. Two PBC patients (2.7%) and six AIH patients (10.5%) had anti-CCP antibodies. The seropositivity for anti-CCP in these autoimmune disease patients was associated with a high frequency of RA association [PBC; 100% (2/2), AIH; 86.4% (5/6)].
Although anti-CCP antibodies may be present in patients with autoimmune liver diseases, almost seropositive patients had concomitant RA. As a result, the measurement of anti-CCP antibodies may therefore be helpful for accurately diagnosing RA in patients with these liver diseases.
测定丙型肝炎病毒（HCV）感染患者、原发性胆汁性肝硬化（PBC）患者及Ⅰ型自身免疫性肝炎（AIH）患者中抗环瓜氨酸肽（anti-CCP）抗体的频率，以评估anti-CCP抗体的特异性。
检测HCV感染患者（n = 45）、PBC患者（n = 73）、AIH患者（n = 55）、类风湿关节炎（RA）患者（n = 48）以及健康受试者（n = 23）血清中的类风湿因子（RF）和anti-CCP抗体。采用第二代酶联免疫吸附测定（ELISA）法检测anti-CCP抗体。
HCV感染患者中未发现anti-CCP升高的血清。2例PBC患者（2.7%）和6例AIH患者（10.5%）存在anti-CCP抗体。这些自身免疫性疾病患者中anti-CCP血清阳性与RA关联的高频率相关[PBC；100%（2/2），AIH；86.4%（5/6）]。
虽然自身免疫性肝病患者可能存在anti-CCP抗体，但几乎所有血清阳性患者都伴有RA。因此，检测anti-CCP抗体可能有助于准确诊断这些肝病患者的RA。
