Rohr P, Veit T D, Scheibel I, Xavier R M, Brenol J C T, Chies J A B, Kvitko K
Departamento de Genética e Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Clin Exp Rheumatol. 2008 Jan-Feb;26(1):151-5.
In this study we have analyzed GSTM1, GSTT1 and GSTP1 polymorphisms in patients with juvenile idiopathic arthritis (JIA), to investigate a possible role of these genes as genetic components of the disease.
A total of 103 individuals (49 oligoarticular, 41 polyarticular and 13 systemic) were analyzed for the three polymorphisms, using a PCR/RFLP methodology.
We have observed significantly increased frequencies of individuals with GSTT1 null genotype in JIA patients comparing to controls (37% x 21%; p=0.0183). There was a 2-fold increased risk (OR 2.2, 95% CI 1.2-4.1) associating the disease with the GSTT1 null genotype. Considering the subgroups (oligoarticular, polyarticular and systemic), the results indicated an association between polyarticular and systemic patients and the GSTT1 null genotype. There was a 2-fold increased risk for polyarticular patients (OR 2.4, 95%, CI 1.1-5.4), and a 4-fold increased risk for systemic patients (OR 4.4, 95%, 1.3-14.5).
The GSTT1 null genotype seems to be involved in polyarticular and systemic JIA.
在本研究中，我们分析了青少年特发性关节炎（JIA）患者的谷胱甘肽S-转移酶M1（GSTM1）、谷胱甘肽S-转移酶T1（GSTT1）和谷胱甘肽S-转移酶P1（GSTP1）基因多态性，以研究这些基因作为该疾病遗传成分的可能作用。
使用聚合酶链反应/限制性片段长度多态性（PCR/RFLP）方法，对总共103名个体（49名单关节型、41名多关节型和13名全身型）进行了这三种多态性分析。
我们观察到，与对照组相比，JIA患者中GSTT1基因缺失基因型个体的频率显著增加（37%对21%；p = 0.0183）。该疾病与GSTT1基因缺失基因型相关的风险增加了2倍（比值比2.2，95%置信区间1.2 - 4.1）。考虑到亚组（单关节型、多关节型和全身型），结果表明多关节型和全身型患者与GSTT1基因缺失基因型之间存在关联。多关节型患者的风险增加了2倍（比值比2.4，95%，置信区间1.1 - 5.4），全身型患者的风险增加了4倍（比值比4.4，95%，1.3 - 14.5）。
GSTT1基因缺失基因型似乎与多关节型和全身型JIA有关。
