Jiang Hong, Zhao Dongdong, Cui Bo, Lu Zhibing, Lü Jingjun, Chen Fang, Bao Minwei
Department of Cardiology, Renmin Hospital of Wuhan University, Wuchang, Wuhan, China.
J Electrocardiol. 2008 Mar-Apr;41(2):152-9. doi: 10.1016/j.jelectrocard.2007.10.001.
The roles of electrical restitution determined by epicardial contact mapping and surface electrocardiogram (ECG) in the inducibility of ventricular fibrillation (VF) were evaluated.
Ten epicardial unipolar electrograms using contact mapping and the surface ECGs were simultaneously recorded in 7 swine. Activation-recovery interval (ARI) and QT-interval restitution curves were constructed. Steady-state pacing protocol was performed to induce VF. Ventricular fibrillation threshold was defined as the longest pacing interval for inducing VF. Statistical correlation analysis was performed to determine the relationship between local ARI restitutions, QT-interval restitution, and ventricular fibrillation threshold.
One hundred thirteen restitution curves were constructed (50 in left ventricular sites, 52 in right ventricular sites, and 11 in surface ECG lead II) from 11 steady-state pacing procedures. Statistical correlation between the slopes of the QT restitution curve and the slopes of regional ARI restitution curves was noted in several mapping sites. Ventricular fibrillation threshold significantly related to the local ARI restitution curve slope for the right ventricular apex (R = 0.752, P = .019) and the QT-interval restitution curve slope (R = 0.802, P = .005).
There is a significant correlation between the local ARI restitutions and the QT-interval restitutions, both of which were associated with VF inducibility.
评估通过心外膜接触标测和体表心电图（ECG）测定的电恢复在心室颤动（VF）诱发中的作用。
在7头猪身上同时记录10个使用接触标测的心外膜单极电图和体表ECG。构建激活-恢复间期（ARI）和QT间期恢复曲线。进行稳态起搏方案以诱发VF。将心室颤动阈值定义为诱发VF的最长起搏间期。进行统计相关性分析以确定局部ARI恢复、QT间期恢复与心室颤动阈值之间的关系。
从11次稳态起搏程序中构建了113条恢复曲线（左心室部位50条，右心室部位52条，体表ECG导联II 11条）。在几个标测部位注意到QT恢复曲线斜率与区域ARI恢复曲线斜率之间存在统计相关性。心室颤动阈值与右心室心尖部的局部ARI恢复曲线斜率（R = 0.752，P = 0.019）和QT间期恢复曲线斜率（R = 0.802，P = 0.005）显著相关。
局部ARI恢复与QT间期恢复之间存在显著相关性，两者均与VF诱发有关。
