Workman Joanna L, Weil Zachary M, Tuthill Christiana R, Nelson Randy J
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Behav Brain Res. 2008 Jun 3;189(2):387-91. doi: 10.1016/j.bbr.2008.01.016. Epub 2008 Feb 5.
This study investigated the effect of maternal pinealectomy and postnatal pinealectomy on affective responses. Siberian hamsters were born to either pinealectomized or sham-operated dams and then underwent pinealectomy or a sham operation. Maternal pinealectomy increased depressive-like responses of offspring in the forced swim test. Maternal pinealectomy increased rearing behaviour and postnatal pinealectomy increased locomotor behaviour in the open field test. These results suggest that prenatal melatonin organizes adult affective responses.
本研究调查了母体松果体切除和产后松果体切除对情感反应的影响。西伯利亚仓鼠出生于松果体切除或假手术的母鼠，然后接受松果体切除或假手术。母体松果体切除增加了子代在强迫游泳试验中的抑郁样反应。母体松果体切除增加了竖毛行为，产后松果体切除增加了旷场试验中的运动行为。这些结果表明，产前褪黑素影响成年后的情感反应。
